Case Presentation25malx quarAmazon's mission is to be Earth's most customer-centric company, Earth’s best employer, and Earth’s safest place to work. Here we present a case of adult NXP-2 positive DM.
SpecificityNXP-2 (also known as anti-MJ), a myositis-specific antibody, has been previously identified in 25% of juvenile dermatomyositis patients, and studies have shown its association with calcinosis and severe muscle weakness as well as potential gastrointestinal involvement. NPX1, NPX2 has potential N-linked glycosylation sites. It is likely to play role in the modification of cellular properties that underlie long-term plasticity. Although two studies of associations between the anti-NPX2 antibodies and cancer in Chinese cohorts have been published, inconsistent results exist.NPX2 (Neuronal Pentraxin 2), 429aa in mouse, 432 in rat and 431 in human (chr 7q21), mainly expressed in brain, pancrease, liver and testis. Amazon npx2 However, he also mentioned that there was no difference in the prevalence of cancer-associated myositis between those with and without anti-NPX2 antibodies (9% vs 8%, P = 0.9).
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